The dramatic rise in the incidence of diabetes worldwide can be attributed to human behavior and lifestyle changes over the last century. In animal researches, the analgesic mechanisms of stem cells in different animal models of neuropathic pain should be explored.Strict glycemic control is the most reliable treatment for diabetic peripheral neuropathy, but expanding knowledge of central and peripheral nervous system processes may help identify therapeutic methods that can effectively target the underlying mechanisms of pathogenesis.īy Sarnarendra Miranpuri, DPM, MD Kush Patel Gurwattan Miranpuri, PhD Abhishek Chopra and Ravinderjit Singh In clinical trials, the type and dosage of the in- fused stem cells, the safety and the grafting efficiency should be further investigated. Stem cell re- searches should focus on both experimental and clinical studies of neuropathic pain in the future. Understanding the molecular mechanisms underlying both positive and negative effects of stem cells on pain processing is very important for the development of novel, specific and effective therapeutic modalities for pain relief.
aggravating pain above the lesion spinal cord segment). Moreover, stem cell treatment does not always exert positive results in SCI- induced chronic pain (e.g. However, it is interesting to point out that peripheral neuropathic pain seems to be more responsive to stem cell therapy than SCI- induced chronic pain. Stem cell transplantation can effectively relieve neuropathic pain under different pathological conditions. Stem cell researches should focus on both experimental and clinical studies of neuropathic pain in the future.
Summary: The analgesic effect of stem cells depends on the capacity to offer a multipotent cellular source for replacing injured neural cells and delivering trophic factors to lesion sites.
Moreover, stem cell treatment does not always exert positive results in SCI-induced chronic pain (e.g. However, it is interesting to point out that peripheral neuropathic pain seems to be more responsive to stem cell therapy than SCI-induced chronic pain. Accumulating evidence has shown that stem cell transplantation has a therapeutic effect on neuropathic pain. Recent findings: Recently, the successful use of stem cell for the treatment of a diverse spectrum of diseases in animals has attracted more attentions from pain scientists. Method: We reviewed recent articles and literatures about stem cells for the treatment of neuropathic pain, in order to identify the types of stem cells, delivery approaches and the advances of stem cells for the treatment of peripheral nerve injury induced neuropathic pain, painful diabetic peripheral neuropathy and spinal cord injury (SCI) induced chronic pain. This article aimed to review important and illustrative results from recent stem cell studies under various neuropathic pain conditions and to interpret their clinical implications for stem cell transplantation. Stem cell transplantation may be an important approach for the treatment of neuropathic pain. Despite multiple therapeutic strategies, the medical community still faces a challenge to treat neuropathic pain in a complete and definitive way, since the pathogenesis of this hypersensitive state is very complex. Aim of review: Neuropathic pain induced by injury to the somatosensory system is a great clinical problem.
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