Due to the various fundamental structural similarities between bsAbs and monoclonal antibodies (mAbs), many of the current bsAb downstream purification methodologies are based on the established purification processes of mAbs, where affinity, charge, size, hydrophobicity and mixed-mode-based purification are frequently employed. The downstream processing of this class of antibodies is therefore of crucial importance in ensuring that these products can be obtained with high purity and yield. 238000011068 load Methods 0.Bispecific antibodies (bsAbs) represent a highly promising class of biotherapeutic modality.238000004191 hydrophobic interaction chromatography Methods 0.000 claims description 159.108090000623 proteins and genes Proteins 0.000 claims description 165.102000004169 proteins and genes Human genes 0.000 claims description 165.239000000203 mixture Substances 0.000 claims abstract description 203.108060003951 Immunoglobulins Proteins 0.000 title claims abstract description 30.102000018358 Immunoglobulins Human genes 0.000 title claims abstract description 30.108020001507 fusion proteins Proteins 0.000 title claims abstract description 447.102000037240 fusion proteins Human genes 0.000 title claims abstract description 447.
Publication of WO2009111347A1 publication Critical patent/WO2009111347A1/en Links Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.) Filing date Publication date Priority to US6785208P priority Critical Priority to US61/067,852 priority Priority to US7410208P priority Priority to US61/074,102 priority Application filed by Biogen Idec Ma Inc. Priority date (The priority date is an assumption and is not a legal conclusion. Inventor Justin Mccue Jonathan Romero Werner Meier Stephen Notarnicola David Evans Richard Macniven Original Assignee Biogen Idec Ma Inc. Google Patents WO2009111347A1 - Purified immunoglobulin fusion proteins and methods of their purification WO2009111347A1 - Purified immunoglobulin fusion proteins and methods of their purification
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